Type

Recombinant

Description

OTOR,alsocalledOtoraplinandMIAL,isasecretedcytokineoftheMIA/OTORfamily.Membersofthisfamily,whichincludeMIA,MIA2,andTANGO,shareaSrchomology-3(SH3)-likedomain.OTORispredominantlyexpressedinthecochleaoftheinnerear,and,toalesserextent,infetalbraintissueandsomecartilagetissues.OTORappearstobeinvolvedinearlychondrogenesisoftheoticcapsule,whichisrequiredfornormalinnereardevelopmentandauditoryfunction.RecombinantHumanOTORisa12.7 kDaglobularproteincontaining112 aminoacidresidues.

AminoAcidSequence

MVHGIFMDRLASKKLCADDECVYTISLASAQEDYNAPDCRFINVKKGQQIYVYSKLVKENGAGEFWAGSVYGDGQDEMGVVGYFPRNLVKEQRVYQEATKEVPTTDIDFFCE

Source

E.coli

Purity

98%

BIOLOGicalActivity

DataNotAvailable.

Endotoxin

Endotoxinlevelis<0.1 ng/μgofprotein(<1EU/μg).

Reconstitution

Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1–1.0 mg/ml.Donotvortex.Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%BSA)andstoreinworkingaliquotsat –20°Cto –80°C.

Storage/Expiration

 –20°C