Type

Recombinant

Description

IL-9 isanimmunoregulatorycytokineproducedbyIL-2 activatedTh4lymphocytes.IL-9 enhancestheproliferationofTlymphocytes,mastcells,erythroidprecursorcellsandmegakaryoblasticleukemiacelllines.Over-expressionofIL-9 hasbeenimplicatedinthepathogenesisofanaplasticlymphomaandHodgkin’s disease.RecombinantRatIL-9 isa14.3 kDaproteinof127 aminoacidresidues,including10 cysteineresiduesthatarefullyconservedbetweenthehumanandmurineproteins.

AminoAcidSequence

MQRCSTSWGIQHTSYLIENLKDDPSSKCSCSANVTSCLCLPIPSDDCTTPCFQEGMSQVTNATQQSKFSPFFFRVKRIVETLKSNKCQFFSCEKPCNQTTAGNTVSFLKSLLKTFQKTEVQVQRSRA

Source

E.coli

Purity

98%

BIOLOGicalActivity

Datanotavailable.

Endotoxin

Endotoxinlevelis<0.1 ng/μgofprotein(<1EU/μg).

Reconstitution

Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1–1.0 mg/ml.Donotvortex.Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%BSA)andstoreinworkingaliquotsat –20°Cto –80°C.

Storage/Expiration

 –20°C