Type

Recombinant

Description

IL-17F,amemberoftheIL-17 familyofstructurallyrelatedcytokines,hasbeenshowntostimulateproliferationandactivationofT-cellsandPBMCs.IL-17Falsoregulatescartilagematrixturnoverandinhibitsangiogenesis.RecombinantMurineIL-17Fisa30.0 kDa,disulfide-linkedhomodimerconsistingoftwo134 aminoacidresiduechains.

AminoAcidSequence

MRKNPKAGVPALQKAGNCPPLEDNTVRVDIRIFNQNQGISVPREFQNRSSSPWDYNITRDPHRFPSEIAEAQCRHSGCINAQGQEDSTMNSVAIQQEILVLRREPQGCSNSFRLEKMLLKVGCTCVKPIVHQAA

Source

E.coli

Purity

98%

BIOLOGicalActivity

Datanotavailable.

Endotoxin

Endotoxinlevelis<0.1 ng/μgofprotein(<1EU/μg).

Reconstitution

Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1–1.0 mg/ml.Donotvortex.Thissolutioncanbestoredat2–8°Cforupto1 week.Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%BSA)andstoreinworkingaliquotsat –20°Cto –80°C.

Storage/Expiration

 –20°C