Type

Recombinant

Description

IL-17Disadisulfide-linkedhomodimeroftwo185 aminoacidpolypeptidechains.ItbelongstotheIL-17 familyofstructurally-relatedcytokinesthatshareahighlyconservedC-terminalregion,butdifferfromoneanotherintheirN-terminalregionsandintheirdistinctBIOLOGicalroles.Thesixknownmembersofthisfamily,IL-17AthroughIL-17F,aresecretedashomodimers.IL-17DhastheABIlitytostimulatetheproductionofIL-6,IL-8 andGM-CSF,andinhibitshemopoiesisofmyeloidProgenitorcellsincolony-formingassays.RecombinantHumanIL-17Disa40.5 kDadisulfide-linkedhomodimeroftwo185 aminoacidpolypeptidechains.

AminoAcidSequence

APRAGRRPARPRGCADRPEELLEQLYGRLAAGVLSAFHHTLQLGPREQARNASCPAGGRPADRRFRPPTNLRSVSPWAYRISYDPARYPRYLPEAYCLCRGCLTGLFGEEDVRFRSAPVYMPTVVLRRTPACAGGRSVYTEAYVTIPVGCTCVPEPEKDADSINSSIDKQGAKLLLGPNDAPAGP

Source

E.coli

Purity

98%

BiologicalActivity

Datanotavailable.

Endotoxin

Endotoxinlevelis<0.1 ng/μgofprotein(<1EU/μg).

Reconstitution

Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.5–1.0 mg/ml.Donotvortex.Thissolutioncanbestoredat2–8°Cforupto1 week.Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%BSA)andstoreinworkingaliquotsat –20°Cto –80°C.

Storage/Expiration

 –20°C