Description
Plasmafibronectinleveliselevatedinseverecoronaryarterydisease.Increasedplasmafibronectinlevelsarerelatedwithvenousthromboembolism(VTE)particularlyinmales,andextendtheprobableassociationbetweenbioMarkersandriskfactorsforarterialatherothrombosisandVTE.Fibronectinplaysaroleinseveralcellularprocesses,includingtissuerepair,embryogenesis,bloodclotting,andcellmigration/adhesion.Fibronectinconsistsintwomainforms:1)asaninsolubleglycoproteindimerthatservesasalinkerintheetracellularmatrixand2)asasolubledisulphidelinkeddimerfoundintheplasma.Theplasmaformisproducedbyhepatocytes,andtheECMformissynthesizedbyfibroblasts,chondrocytes,endothelialcells,macrophages,aswellascertainepithelialcells.Fibronectinalostakespartasageneralcelladhesionmoleculebyanchoringcellstocollagenorproteoglycansubstrates.FibronectinorganizescellularinteractionwiththeECMbybindingtodifferentcomponentsoftheextracellularmatrixandtomembrane-boundFibronectinreceptorsoncellsurfaces.
Source
Humanplasma
Purity
Greaterthan95.0%asdeterminedbyanalysisbySDS-PAGE.
Formulation
TheFibronectinwaslyophilizedfromaconcentrated1mg/mlsolutioncontaining0.05MTrisHClpH-7.5 and0.1M NaCl.
Shipping
Atambienttemperature.Uponreceipt,storetheproductatthetemperaturerecommended below.
Storage/Expiration
LyophilizedFibronectinalthoughstableatroomtemperaturefor1 week,shouldbestoreddesiccatedbelow –18°C.UponreconstitutionFibronectinshouldbestoredat4°Cbetween2–7daysandforfutureusebelow –18°C.Pleasepreventfreeze-thawcycles.
PhysicalAppearance
Sterilefilteredwhitelyophilized(freeze-dried)powder.
