Type
Synthetic
Description
Buserelinbelongstothegroupofgonadotrophinreleasinghormone(gonadorelin)analogues(LHRHagoNIST).Itactsonthepituitaryglandwhichcontrolstheamountofmanydifferenttypesofhormones(chemicalmessengers).Italterstheamountofhormones,particularlytheoestrogensandrogens.Thisalterationofhormonelevelscanbeexploitedtotreatcancersoftheprostategland,whicharestimulatedtogrowbytestosterone.Buserelinlowersthelevelsoftestosterone,whichstarvesthetumouroftestosteroneandcausesittoshrink.Buserelincontains9 aminoacidsGlu-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEtandhavingamolecularweightof1239.44 Dalton.
Purity
Greaterthan98.0%asdeterminedby:-(a)AnalysisbyRP-HPLC.-(b)AnalysisbySDS-PAGE.
Formulation
TheBuserelinpeptidewaslyophilizedwithnoadditives.
Shipping
Atambienttemperature.Uponreceipt,storetheproductatthetemperaturerecommended below.
Storage/Expiration
LyophilizedBuserelinalthoughstableatroomtemperaturefor3 weeks,shouldbestoreddesiccatedbelow –18°C.UponreconstitutionBuserelinshouldbestoredat4°Cbetween2–7daysandforfutureusebelow –18°C.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Pleasepreventfreeze-thawcycles.
PhysicalAppearance
Sterilefilteredwhitelyophilized(freeze-dried)powder.
