Type

Recombinant

Description

APRIL,amemberoftheTNFsuperfamily,isexpressedinmonocytes,macrophages,certaintransformedcelllines,certaincancersofthecolon,andlymphoidtissues.APRIL,alongwithanotherTNFfamilymember,BAFF,competesfortworeceptors,TACIandBCMA.APRILhastheABIlitytostimulateproliferationofvarioustumorcelllines,includingJurkatTcellsandMCF-7 carcinomacells.LikeBAFF,APRILalsostimulatestheproliferationofBandTcells.ThehumanAPRILgenecodesforatleastfouralternativelysplicedtranscriptionalvariants,whichgiverisetodifferentisoformsoftheAPRILprecursorprotein.Allisoformscanbecleavedbytheprotease,furin,toreleaseasolubleC-terminalfragment,whichcomprisestheTNF-likereceptorbindingoftheAPRILprecursor.RecombinanthumanAPRILisasoluble16.3 kDaprotein,consistingof146 aminoacidresidues.

AminoAcidSequence

AVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL

Source

Hi-5Insectcells

Purity

95%

BIOLOGicalActivity

MeasuredbyitsabilitytoinducecelldeathinJurkat cells.

Storage/Expiration

 –20°C