Type
Recombinant
Description
AITRL,amemberoftheTNFsuperfamily,isexpressedinendothelialcells,andsignalsthroughtheAITRreceptor.AITRLregulatesT-cellproliferationandsurvival,andeffectuatestheinteractionbetweenTlymphocytesandendothelialcells.TheAITRLgenecodesforatypeIItransmembraneproteincomprisedof177 aminoacids,includinga28 aminoacidcytoplasmicregion,a21 aminoacidtransmembranedomainanda128 aminoacidextracellulardomain.RecombinantHumansolubleAITRLisa14.4 kDaprotein,containing127 aminoacidresiduescorrespondingtotheextracellulardomainof AITRL.
AminoAcidSequence
METAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS
Source
E.coli
Purity
98%
BIOLOGicalActivity
DeterminedbyitsABIlitytostimulateIL-8 productionbyhumanPBMCusingaconcentrationrangeof1.0–10.0 ng/ml.Note:ResultsmayvarywithPBMCdonors.
Storage/Expiration
–20°C
