Type
Recombinant
Description
4–1BBReceptor,amemberoftheTNFsuperfamilyofreceptors,ismainlyexpressedonthesurfaceofavarietyofTcells,butalsofoundinBcells,monocytes,andvarioustransformedcelllines.4–1BBReceptorbindsto4–1BBLtoprovideaco-stimulatorysignalforTlymphocytes.Signalingby4–1BBReceptorhasbeenimplicatedintheantigen-presentationprocessandgenerationofcytotoxicTcells.Thehuman4–1BBReceptorgenecodesfora255 aminoacidtypeI transmembraneproteincontaininga17 aminoacidN-terminalsignalsequence,a169 aminoacidextracellulardomain,a27 aminoacidtransmembranedomainanda42 aminoacidcytoplasmicdomain.RecombinantHumansoluble4–1BBReceptorisa167 aminoacidpolypeptide(17.7 kDa),whichcontainsthecysteine-richTNFR-likeextracellulardomainof4–1BBReceptor.
AminoAcidSequence
MERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKNCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHS
Source
E.coli
Purity
98%
BIOLOGicalActivity
Determinedbyitsinhibitoryeffectofthe4–1BBLmediatedstimulationofIL-8 productionbyhumanPBMC.About90%ofinibitionwasseenusingaconcentrationof1µgforboth4–1BBLand4–1BBR.
Storage/Expiration
–20°C